The world’s only poisonous primate

From the live-and-learn department, as discussed in today’s Guardian: the world has several venomous mammals (including shrews and the platypus), but there’s only one venomous primate. It’s the slow loris, which comprises three species (all from south or southeast Asia) in the genus Nycticebus.

Here’s a description of the situation from Dr. Brian Grieg Fry, who works on these creatures.

Unlike most primates, the lorises do not leap through trees. Rather they carefully and methodically move their feet in an almost chameleon-like manner, an impression greatly enhanced by thumbs that are more opposing than other primates. Specialised blood vessels allow them to grip on for hours. (This seems especially true when I’m trying to get some work done and Elvie will not let go of my hand and let me type!) When disturbed, (like trying to press return on my keyboard) lorises make a very unique low buzzing sound, much as if they were trying to play the digeridoo but without a didge or using their lips! True talent. In addition to this, when Lorises feel that battle stations is necessary, they fold their arms into a diamond around their head. While this looks incredible cute and useless as a defence mechanism, it allows for them to quickly take the toxin from their fore arms into their mouth in preparation for biting. This is reminiscent of karate moves at the last draw corral. Ah, I see you know the grasshopper, but do you know the Slow Loris?!

Having worked extensively with the lorises for the last couple years I am absolutely smitten with them. However, while they have the face of those cute and cuddly gremlins, they have the attitude of the evil, after-midnight flipside. With disproportionately huge and sharp canine teeth (very fang-like) and powerful jaw muscles their bites alone can be absolutely agonising. However, the pain is compounded by factors beyond the simple tissue trauma caused by the mechanical damage from the powerful jaws. The lorises are actually toxic! On the inside of their elbows, sebaceous tissue secretes a toxin (like sweat pores, which is rather fitting since the toxic mixture smells remarkably like sweaty socks). The lorises take it into their mouth and deliver it in the bite. It is not the upper and lower jaw vampire like canine teeth that deliver this toxin. It is the innocuously small teeth in the front of the lower jaw which slope forward and help conduct the saliva into the wound. One time I was working with the large lorises in the research collection and a visiting vet student from Belgium saw me putting on big thick gloves. She asked why I was doing that and I told her about the viciousness of the lorises. She looked at them and said that they couldn’t hurt anyone and besides, it wouldn’t be any fun to use gloves. I raised an eyebrow and said ‘be my guest’. Two hours later, with her hand still painfully throbbing merrily away despite the many ice packs on it, I asked her if she was having fun yet!

Of course this is an evolutionary puzzle, since if this is an adaptation, which it certainly appears to be, what were the intermediate evolutionary stages of the “poison patch,” and how were they adaptive? A paper in Naturwissenschaften suggests that the active protein in loris “venom” is an allergen, most similar to one seen in cats.

At any rate, slow lorises aren’t always mean.  Here’s one enjoying a good tickling.  Take that, P. Z.!!!

Thanks to Matthew Cobb for calling this to my attention. By the way, he’s just published a great new book on the French Resistance. Yes, it’s odd for a biologist to do this, but he’s a polymath.

12 Comments

  1. Posted July 6, 2009 at 8:35 am | Permalink

    I love cute but deadly. Reminds me of my own kids.

  2. Hempenstein
    Posted July 6, 2009 at 9:21 am | Permalink

    Video is cute and toxin protein shows compelling relationship to a feline protein, ergo…

    I wonder if we have any related sebaceous proteins? Presumably they scanned the human genome for that, except that I just noticed that the publication date is 2003.

    • hempenstein
      Posted July 6, 2009 at 3:43 pm | Permalink

      Seems that they got two N-terminal sequences from the Loris: AICPALEKHANLFLKGTTDEFLNNVKNFVKSSEIL
      and
      CPLFYGVFGALVTGDKNLLDSFLDKVSGTEP
      which clearly behave as tho disulfide linked.

      Running a few quick BLAST searches, the first is most similar to mouse salivary androgen-binding alpha subunit as well as a protein from cow, while the closest similarity to the second sequence is bovine secretoglobulin. No apparent human or other primate homologs when specifically trying to force finding something from the human genome (caveat: I may not be running the human search properly). I was sorta hoping there might be a human pseudogene that when translated would show some similarity.

      Further noted in passing: a crystal structure of the cat allergen protein is apparently now available too.

  3. Posted July 6, 2009 at 9:41 am | Permalink

    I’d like to see an ID explanation of why loris venom was “designed” to be dispensed in such an inconvenient manner for the loris. I’m not sure of what the evolutionary explanation is, but evolution is chock-full of contingent limitations, and this no doubt is the result of said limitations.

    Then again, I’d like an ID explanation (a real one) for anything at all.

    Glen Davidson
    http://tinyurl.com/mxaa3p

  4. Sili
    Posted July 6, 2009 at 1:50 pm | Permalink

    Nope, sorry, still don’t like primates.

    Guess I see them as too much of an evolutionary competitor.

    Or summat.

  5. newenglandbob
    Posted July 6, 2009 at 2:34 pm | Permalink

    Nycticebus coucang or N. coucang is so much cooler of a name than slow loris.

    Shocking:

    So, when illegal traders catch them and sell them on, they usually remove the hapless creatures’ teeth – with wire cutters.

    The link above to
    Dr. Brian Grieg Fry has an incredible amount of information.

    • hempenstein
      Posted July 6, 2009 at 3:08 pm | Permalink

      “when illegal traders catch them …. they usually remove the hapless creatures’ teeth – with wire cutters”

      One more example of what swine humans can be, and that’s of course a deep insult to pigs.

  6. Damian
    Posted July 6, 2009 at 4:17 pm | Permalink

    Ha! Last night, I watched an episode of “The Snake Buster”, where Bruce George (the snake buster), as well as Dr. Bryan and Lexie Fry, went looking for, if I remember correctly, a Death Adder (as well as other snakes) for venom research. And they found a new species!

    Oh, and Bruce George was bitten by a really tiny snake, but didn’t realize it at the time. They finished searching for snakes in the dark, and the next minute the camera cut to Brian Fry in a hospital, saying that Bruce George had fallen really ill.

    He’d been bitten by a snake that had no anti-venom, so they had to use something generic, in the hope that it worked. Luckily it did, but Bruce George described the experience as like being smashed with a hammer and a chisel behind the eye socket, over and over. He was also completely paralyzed for a short while.

    Dr Bryan Fry has posted at Pharyngula on a couple of occasions (Evolving Snake Fangs). He appears to be a really nice guy, with a really, really cool job.

  7. Joshua Slocum
    Posted July 6, 2009 at 7:24 pm | Permalink

    Why is this critter not on my bed, snuggled up next to my pillow, in a pile-‘o-love with my kittehs? Cripes, he’s so damned cute I want to eat. him. up.

  8. Posted July 7, 2009 at 1:23 am | Permalink

    “Justify your existence, obey God.”

  9. Posted July 8, 2009 at 3:18 am | Permalink

    It’s rather odd that you should post this now…there’s a new denial-of-service attack against the Apache web server called slowloris.

    http://lwn.net/Articles/338407/

  10. Onek
    Posted January 31, 2010 at 9:43 pm | Permalink

    That Thing Shoots Poinsons from its elbows…and when it mixed with it salyva..its pretty nasty…. and armed with a cute face LOLOLOLOL XD


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