O noes! Another species of human in Eurasia?

The story of Homo keeps getting weirder and weirder.  Just as I was getting used to the idea that Neandertals and more modern Homo sapiens may have made the beast with two backs,  somebody calls my attention to yet another lineage of Homo that may have coexisted with both of them.  This conclusion comes from DNA extracted from a single bone and described in a paper by Krause et al. (and, of course, Svante Pääbo) in the April 8 issue of Nature.

First, a wee bit of background.  We now know (or at least think) that there were three migrations of our relatives out of Africa:

The first migration of Homo erectus from Africa throughout Eurasia (and maybe to Indonesia), beginning 1.9 million years ago. H. erectus seems to have vanished without leaving descendants, though we’re not sure about this. And the “hobbit,” H. floresiensis, which lived in Indonesia until only 12,000 years ago, may have come from this migration.

The migration that gave rise to Neandertals, beginning about 500,000 years ago. We now think that these individuals went extinct without leaving descendants, but left a few of their genes by hybridizing with members of the third migration.

The final migration that took place about 60,000 years ago, giving rise, so we think, to all modern humans.

But the new paper suggests that there may have been a fourth out-of-Africa migration.  The genetic data suggesting this comes from a single finger bone found in a cave in the Altai Mountains in southern Siberia (see circled location in Fig. 1 below). While the cave may have been sporadically occupied by hominins starting 125,000 years ago, the bone comes from a stratum dating between 30,000 and 48,000 years ago.

Fig. 1.  Locations of specimens used in DNA analysis.  Modern humans in gray, Neandertals in blue, Denisova individual circled in red.

After extracting the DNA from this bone (and again let us remember how remarkable an achievement this is), the authors sequenced the entire mitochondrial genome.  They then compared its sequence to that of several modern human populations, some already-sequenced Neanderthal mtDNAs, and a bonobo and a chimp as outgroups.  What they found, as seen in Figure 2 below, is that the Denisova sample was an outgroup to Neandertals and modern humans; that is, it diverged from the (Neandertal + modern human) lineage roughly a million years ago, well before the divergence of the Neandertal and modern human lineages from each other.

Fig. 2.  Mitochondrial DNA phylogeny of modern humans (gray), Neandertals (blue) and the individual from Denisova (red)

What this means is that this individual could not have been part of either of the last two out-of-Africa migrations, nor could it have been part of the earlier migration 1.9 million years ago, since it diverged from our own lineage well after our lineage diverged from the ancestors of Homo erectus.  This tentatively suggests that there was yet another migration out of Africa—a fourth—that gave rise to the Denisova individual and the population to which it belonged.

Further, this “species” could have been a contemporary of Neandertals and modern humans.  The authors note that individuals with Neandertal-like mtDNA lived only 100 km away from Denisova at about the same time, and other artifacts suggest that “modern” humans also lived in the region around 40,000 years ago.  It’s possible, then, that there could have been three evolutionarily independent species of hominins living in the same area of Asia at about the same time. (We already know a similar situation held for earlier species of hominins in Africa).  More opportunities for hybridization!

Now this conclusion is tentative, for it’s based on mitochondrial DNA from a single individual. It’s possible that there was simply an ancient mitochondrial DNA kicking around in the Neandertal genome, and this individual was simply a Neandertal that had it.  This can be resolved by looking at both other individuals and at the nuclear DNA of Denisova samples. (I don’t know if there are enough bones to provide this).

And of course we can’t yet tell if this individual was a member of a new species of Homo.  That’s hard to tell from mitochondrial DNA, although zoologists often blithely (and, I think, erroneously) diagnose new species of animals based on an observed difference in mtDNA sequences.

Steve Gould once wrote that when he taught human evolution each year, his first job was to throw out all the lecture notes from the preceding year.  With our remarkable ability to recover and sequence DNA from our ancestors and relatives, and the use of “phylogeography” to trace human movement using present-day genetic patterns, the field is moving even faster now.   I am certain there are big surprises in store.

Fig. 3.  Altai Mountains of Siberia, a view from just above the cave at Denisova where the new specimen was found (Photo by J. Krause, from Nature).

__________

J. Krause, Q. Fu, J. M. Good, B. Viola, M. V. Shunkov, A. P. Derevianko and S. Pääbo.  2010.  The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature 464:838-839

18 Comments

  1. Posted May 13, 2010 at 7:08 am | Permalink

    I often find that fingers point the way.

  2. Posted May 13, 2010 at 7:56 am | Permalink

    I guess now would be a good time to unleash my manuscript entitled: “Polyeroticism and the Pleistocene.”

  3. Sili
    Posted May 13, 2010 at 8:17 am | Permalink

    tossed the salad

    I’m pretty sure that wouldn’t show up in any genome …

  4. NewEnglandBob
    Posted May 13, 2010 at 8:18 am | Permalink

    Great stuff. Better than any novel. L’Chaim.

  5. Posted May 13, 2010 at 8:38 am | Permalink

    OT, you are getting ads for Scientology.org. Ick.

  6. Chris
    Posted May 13, 2010 at 8:43 am | Permalink

    Jerry, perhaps you do know the specific meaning of “tossing salad,” but just in case you’re thinking it means fornication, it actually means, to put it delicately, stimulating the anus with the tongue.

    • whyevolutionistrue
      Posted May 13, 2010 at 8:49 am | Permalink

      Oh dear, we used it in college to refer to fornication. Well, Google suggests you are right, so I’ll change it. Live and learn.

    • Artikcat
      Posted May 13, 2010 at 10:44 am | Permalink

      “stimulating the anus”? what is this supposed to mean?

      • Tulse
        Posted May 13, 2010 at 12:25 pm | Permalink

        If you have to ask, you probably don’t want to know.

        • Artikcat
          Posted May 13, 2010 at 2:59 pm | Permalink

          oh yes .. i do..anus is empty: a black hole.

        • Torbjörn Larsson, OM
          Posted May 13, 2010 at 4:43 pm | Permalink

          Either that, or WEIT is asked to start a fan service.

          Now _I_ don’t want to know. :-o

  7. MoonShark
    Posted May 13, 2010 at 9:07 am | Permalink

    “Neandertals may have tossed the salad with more modern Homo sapiens.”

    Um. Okay. Is that your professional opinion as a biologist, or just some weird kinky wishful thinking? :p

    • MoonShark
      Posted May 13, 2010 at 9:08 am | Permalink

      (sorry, wrote and then got distracted for a while before posting)

  8. Posted May 13, 2010 at 1:04 pm | Permalink

    And it gets better. According to a study by Jeffrey Long et al., discussed recently in New Scientist, H. neandertalensis is not the only non-human hominin our dear ancestors did the beast with two backs with. Sexual intercouse with H. erectus and/or H. floresiensis are serious candidates to explain why there’s “a spike in genetic diversity in Indo-Pacific peoples, dating to around 40,000 years ago”.

    • Torbjörn Larsson, OM
      Posted May 13, 2010 at 4:40 pm | Permalink

      Yes, if they were entirely correct in the first prediction (non-africans, ~ 60 000 years ago), why wouldn’t it be likely they got the second one correct (Oceanien, ~ 40 000 years ago).

      And if all recent H. sapiens neanderthalensis (as I guess we would have to call them any time now?) ancestry is accounted for, that should make the H. erectus idea the main hypothesis I take it. At least for me, because this layman can’t see how you can separate the Denisova specimen from erectus. :-D (Well, it’s a paywall.)

      Also interesting, I don’t remember who dug up this a few days ago, but the ~ 1 Ma Asian separation is the same time the North America human lice genetically branched from the rest, as I believe is how Carl Zimmer describes it.

      [If you take some or all of these observations and try to make the simplest hypothesis, I guess you may predict something interesting happening in Asia at least once around 40 000 years ago. Maybe the respectively descendants of those meetings, Of Lice and Men, was lost (out-competed) in Asia but survived with migrating populations?]

  9. Dave B.
    Posted May 13, 2010 at 2:16 pm | Permalink

    “The final migration…giving rise, so we think, to all modern humans”

    should read,

    “The final migration…giving rise, so we think, to all modern non-African humans.”

  10. oldfuzz
    Posted May 13, 2010 at 5:18 pm | Permalink

    Just when I think I’m getting a better grip on human evolution… surprise!!!

    Speaking of human evolution and Mitochondrial markers, is <a href="https://genographic.nationalgeographic.com/genographic/index.html"The Genographic Project on the National Geographic website a good place for the interested pedestrian?


5 Trackbacks/Pingbacks

  1. [...] http://whyevolutionistrue.wordpress.com/2010/05/13/o-noes-another-species-of-human-in-eurasia/ [...]

  2. [...] O noes! Another species of human in Eurasia? The story of Homo keeps getting weirder and weirder. Just as I was getting used to the idea that Neandertals and more modern Homo sapiens may have made the beast with two backs, somebody calls my attention to yet another lineage of Homo that may have coexisted with both of them. This conclusion comes from DNA extracted from a single bone and described in a paper by Krause et al. (and, of course, Svante Pääbo) in the April 8 issue of Nature. [...]

  3. [...] Evolution: was there yet another migration out of Africa or was there yet another human-like species? The story of Homo keeps getting weirder and weirder. Just as I was getting used to the idea that [...]

  4. [...] discovery of hybridization between archaic humans and “modern” Homo sapiens.  (This is the Denisova fossil that I wrote about [...]

  5. [...] haben wir es ebenfalls mit einer zeitlichen Diskrepanz zu tun. Der Spiegel und Jerry Coyne beschreiben einen fossilen Finger aus einer Höhle in Denisova mitten in Asien, dem man noch DNA [...]

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